免疫佐劑，是一類(lèi)可以增強(qiáng)抗原免疫原性的免疫調(diào)節(jié)分子、化合物或大分子復(fù)合物。大多數(shù)佐劑可以通過(guò)啟動(dòng)先天免疫系統(tǒng)來(lái)輔助抗原應(yīng)答。先天免疫系統(tǒng)通過(guò)模式識(shí)別受體（pattern recognition receptor，PRR）來(lái)感知各種微生物表達(dá)的病原體相關(guān)分子模式（PAMPs）的存在，激活對(duì)病原體的先天性免疫信號(hào)通路并調(diào)節(jié)適應(yīng)性免疫應(yīng)答。添加天然或人工合成的佐劑分子有助于恢復(fù)或改進(jìn)純化抗原的免疫原性，調(diào)節(jié)免疫應(yīng)答類(lèi)型，在現(xiàn)代疫苗學(xué)研究中具有重要意義。含 CpG 序列的寡脫氧核苷酸（oligonucleotide，ODN）可模擬哺乳動(dòng)物免疫系統(tǒng)的“危險(xiǎn)信號(hào)”，參與機(jī)體免疫應(yīng)答的調(diào)節(jié)，增強(qiáng)疫苗的免疫原性。

  艾美捷科技為您推薦Enzo Life Sciences精品低內(nèi)毒素的CpG ODN，寡聚脫氧核苷酸全家族產(chǎn)品。

 * 更多CpG ODN，寡聚脫氧核苷酸產(chǎn)品，歡迎垂詢(xún)艾美捷。

* 上述產(chǎn)品，僅供科研使用，不得用于醫(yī)療. 

【CpG ODN，寡聚脫氧核苷酸全家族產(chǎn)品優(yōu)勢(shì)】

1、無(wú)內(nèi)毒素水，ddWater 

2、除對(duì)照產(chǎn)品外，產(chǎn)品內(nèi)均已提供陰性對(duì)照 

3、無(wú)菌，凍干粉，內(nèi)毒素<0.002EU/?g 

4、BULK：可用于體內(nèi)實(shí)驗(yàn)  

【Cell文章鑒賞】

IF=66.8, 《Systematic discovery of TLR signaling components delineates viral-sensing circuits 》,Cell

【Enzo精品低內(nèi)毒素的CpG ODN，寡聚脫氧核苷酸，更多發(fā)表文章】

• Ban, T., Kikuchi, M., Sato, G.R. et al. Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease. Nat Commun12, 4379 (2021).

• Contact-dependent inhibition of HIV-1 replication in ex vivo human tonsil cultures by polymorphonuclear neutrophils: T. Reif, et al.; Cell Rep. Med. 2, 100317 (2021)

• Homeostatic and Pathogenic Roles of GM3 Ganglioside Molecular Species in TLR4 Signaling in Obesity: H. Kanoh, et al.; EMBO J. 39, e101732 (2020)

• Murakami, Yuki, et al. "Increased regulatory B cells are involved in immune evasion in patients with gastric cancer." Scientific reports 9.1 (2019): 1-9.

• Maatouk, L., Compagnion, AC., Sauvage, MA.Cd. et al. TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons. Nat Commun9, 2450 (2018).

• Okamura, T., Sumitomo, S., Morita, K. et al. TGF-β3-expressing CD4+CD25?LAG3+ regulatory T cells control humoral immune responses. Nat Commun6, 6329 (2015).

• Chevrier, Nicolas et al. "Systematic discovery of TLR signaling components delineates viral-sensing circuits". Cell vol .147,4 (2011): 853-67.

• Larson, S. R., et al. "Ly6C+ monocyte efferocytosis and cross-presentation of cell-associated antigens." Cell Death & Differentiation 23.6 (2016): 997-1003.

• Jia, Xianxian, et al. "CCK 8 negatively regulates the TLR 9‐induced activation of human peripheral blood p DC s by targeting TRAF 6 signaling." European Journal of Immunology 44.2 (2014): 489-499.

• TLR9-signaling is required for turning retinoic acid into a potent stimulator of RP105 (CD180)-mediated proliferation and IgG synthesis in human memory B cells: A. Eriksen, et al.; Cell. Immunol. 279, 87 (2012)

• Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1: S. Keck, et al.; J. Immunol. 184, 5809 (2010)

• Cutting edge: the mechanism of invariant NKT cell responses to viral danger signals: A.J. Tyznik, et al.; J. Immunol. 181, 4452 (2008)

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