腎素-血管緊張素系統(tǒng)對于控制血壓至關(guān)重要。在血管緊張素原蛋白水解加工產(chǎn)生的不同肽中，八肽血管緊張素 II （AII） 是參與高血壓疾病病理生理學(xué)的主要激素，因為它介導(dǎo)血管收縮作用。它是允許正確估計腎素-血管緊張素系統(tǒng)的首選靶標(biāo)。

作為Bertin Bioreagent全國總代理，艾美捷科技強(qiáng)烈推薦Bertin Bioreagent熱銷產(chǎn)品血管緊張素II SPIE-IA試劑盒。產(chǎn)品僅用于科研，不可用于臨床診斷。

血管緊張素II SPIE-IA試劑盒：

文獻(xiàn)參考：

PRODUCT EXPLANATION: ACETYLCHOLINESTERASE MARKER IN ENZYME-IMMUNOASSAYS

Grassi J., Pradelles P. Compounds labelled by the acetylcholinesterase of Electrophorus Electricus. Its preparation process and its use as a tracer or marquer in enzymo-immunological determinations. United States patent, N° 1,047,330. September 10, 1991

Grassi J., Pradelles P. The use of Acetylcholinesterase as a Universal marker in Enzyme-Immunoassays. Proceedings of the Third International Meeting on Cholinesterases, American Chemical Society (1991)

Pradelles P., Grassi J., Maclouf J. Enzyme Immunoassays of Eicosanoids Using Acetylcholinesterase. Methods in Enzymology (1990), vol. 187, 24-34

PRODUCT EXPLANATION: ANGIOTENSIN II

Paulis L, Unger T. Novel therapeutic targets for hypertension Nat Rev Cardiol. 2010 Aug;7(8):431-41

PRODUCT EXPLANATION: KIT DEVELOPMENT

Volland H, Pradelles P, Ronco P, Azizi M, Simon D, Créminon C, Grassi J. A solid-phase immobilized epitope immunoassay (SPIE-IA) permitting very sensitive and specific measurement of angiotensin II in plasma. J Immunol Methods. 1999 Aug 31;228(1-2):37-47

Pradelles Ph. Immunometric determination of an antigen or hapten. United states patent, N°5,476,770. December 19; 1995

Kohara K, Tabuchi Y, Senanayake P, Brosnihan KB, Ferrario CM. Reassessment of plasma angiotensins measurement: effects of protease inhibitors and sample handling procedures. Peptides. 1991 Sep-Oct;12(5):1135-41

Grassi J, Créminon C, Frobert Y, Etienne E, Ezan E, Volland H, Pradelles P. Two different approaches for developing immunometric assays of haptens. Clin Chem. 1996 Sep;42(9):1532-6

Valentin MA, Ma S, Zhao A, Legay F, Avrameas A. Validation of immunoassay for protein biomarkers: Bioanalytical study plan implementation to support pre-clinical and clinical studies. J Pharm Biomed Anal. (2011) 55(5): 869-877

European Medicines Agency. Guideline on bioanalytical method validation, 21 July 2011

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