Jena Bioscience-6-硫代-GTP的應(yīng)用：

對(duì)大腸桿菌 CTP 合酶的變構(gòu)作用[1]

抑制 Vac-1-Rac 信號(hào)轉(zhuǎn)導(dǎo)[2]

通過阻斷 GTPase 激活進(jìn)行免疫抑制[3, 4]

免疫抑制藥物（移植、炎癥）[1, 4]

艾美捷Jena Bioscience 6-硫代-GTP#NU-1106S參數(shù)：

適合一般實(shí)驗(yàn)室使用。

運(yùn)輸：通過凝膠包運(yùn)輸

儲(chǔ)存條件：儲(chǔ)存于 -20 °C

可以短期暴露于環(huán)境溫度（累計(jì)最多 1 周）。

保質(zhì)期：交貨后12個(gè)月

分子式： C 10 H 16 N 5 O 13 P 3 S（游離酸）

分子量： 539.24 g/mol（游離酸）

精確質(zhì)量： 538.97 g/mol（游離酸）

CAS#： 17670-19-8

純度： ≥95%（HPLC）

形式：水溶液

顏色：無色至微黃色

濃度： 10 mM - 11 mM

pH值： 7.5±0.5

光譜性質(zhì)： λ max  257 nm，ε 8.8 L mmol ^-1  cm ^-1 (Tris-HCl pH 7.5)，λ max  342 nm，ε 24.8 L mmol ^-1  cm ^-1 (Tris-HCl pH 7.5)

Jena Bioscience-6-硫代-GTP文獻(xiàn)參考：

[1] Lunn et al. (2008) Structural requirements for the activation of Escherichia coli CTP synthase by the allosteric effector GTP are stringent, but requirements for inhibition are lax. J. Biol Chem. 283:2010.

[2] Wang et al. (2007) Enhanced cardiac allograft survival by Vav1-Rac signaling blockade in a mouse model. Transplant Immunology 18:53.

[3] Poppe et al. (2005) Azothioprine suppresses Ezrin-Radixin-Moesin-dependent T cell-APC conjugation through inhibition of Vav Guanosine exchange activity on Rac proteins. J. Immunology 176:640.

[4] Tiede et al. (2003) CD28-dependent Rac1 activation is the molecular target of azathioprine in primary human CD4+t lymphocytes. J. Clinical Investigation 111:1133.

Karner et al. (2010) Determination of 6-thioguanosine diphosphate and triphosphate and nucleoside diphosphate kinase activity in erythrocytes: novel targets for thiopurine therapy? Ther. Drug Monit. 32 (2):119.

Bao et al. (2008) Coordination of two sequential ester-transfer reactions: exogenous guanosine binding promotes the subsequent wG binding to a group I intron. Nucleic Acids Research 36 (21):6934.

Du et al. (2007) Enhanced cardiac allograft survival by Vav1-Rac signalling blockade in a mouse model. Transplant Immunology 18 (1): 53.

Pestova et al. (2006) Specific functional interactions of nucleotides at key -3 and +4 positions flanking the initiation codon with components of the mammalian 48S translation initiation complex. Genes & Development 20:624.

Neurath et al. (2005) 6-Thioguanosine Diphosphate and Triphosphate Levels in Red Blood Cells and Response to Azathioprine Therapy in Crohn's Disease. Clinical Gastroenterology and Hepatology 3 (10): 1007.

Poland et al. (1997) Entrapment of 6-thiophosphoryl-IMP in the active site of crystalline adenylosuccinate synthetase from Escherichia coli. J. Biol. Chem. 272 (24):15200.

Yarbrough et al. (1985) Kinetics of interaction of 2-amino-6-mercapto-9-beta-ribofuranosylpurine 5'-triphosphate with bovine brain tubulin. Biochemistry-US 24 (7):1708.

Fishback et al. (1984) Interaction of 6-mercapto-GTP with bovine brain tubulin - equilibrium aspects. J. Biol. Chem. 259 (3):1968.

Jena Bioscience-6-硫代-GTP相關(guān)產(chǎn)品：

CGR-101, Silicone Grease

EN-109, BseCI

NU-1101, N6-Methyl-ATP

NU-1107, Guanosine-3',5'-bisphosphate

NU-1110, 6-Mercaptopurine-riboside-5'-triphosphate

NU-112, 8-Bromo-ADP

NU-118, 8-Bromo-GTP

NU-124, 8-Bromo-GDP

NU-201, Mant-ADP

NU-204, Mant-GDP

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