Jena bioscience--2-Thio-UTP：s、2UTP、2-硫代-UTP、2-硫尿苷-5'-三磷酸鈉鹽Cat. No. Amount

NU-1151S 10 ?l (100 mM)

NU-1151L 5 x 10 ?l (100 mM)

艾美捷2-Thio-UTP：

貨號：NU-1151L

運輸：使用凝膠包裝運輸

儲存條件：需在-20°C下儲存，可以短期（累計不超過1周）暴露在室溫下。

保質(zhì)期：自交貨日期起12個月

分子式：C9H15N2O14P3S（游離酸）

分子量：500.21 g/mol（游離酸）

精確質(zhì)量：499.95 g/mol（游離酸）

CAS號：35763-29-2

純度：≥ 95%（高效液相色譜法）

形態(tài)：水溶液

顏色：無色至微黃

濃度：100 mM - 110 mM

pH值：7.5 ±0.5

光譜特性：最大吸收波長274 nm，摩爾吸光系數(shù)14.2 L mmol^-1 cm^-1（Tris-HCl pH 7.5）

特定配體：

用于嘌呤能受體的配體：

在P2Y2受體上具有強(qiáng)效和選擇性的激動劑[1,2,3,4]

相關(guān)產(chǎn)品：

高產(chǎn)T7 RNA合成試劑盒，#RNT-101

2-Thio-UTP參考文獻(xiàn)：

[1] Higgins et al. (2014) Nucleotides Regulate Secretion of the Inflammatory Chemokine CCL2 from Human Macrophages and Monocytes. Mediators Inflamm. 293925.

[2] Zizzo M. et al. (2012) Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum. Purinergic Signal. 8 (2):275.

[3] Ko et al. (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg. Med. Chem. 16 (12):6319.

[4] El-Tayeb et al. (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J. Med. Chem. 49 (24):7076.

Kormann et al. (2011) Expression of therapeutic proteins after delivery of chemically modified mRNA in mice. Nature Biotechnology 29:154.

Warren et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7 (5):618