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前列腺素E2(Prostaglandin E2 Receptor, PGE2)是花生四烯酸在很多細(xì)胞中代謝的主要產(chǎn)物。跟很多類花生酸一樣,PGE2不會(huì)預(yù)先存在于細(xì)胞中。當(dāng)細(xì)胞活化或是存在外源的花生四烯酸時(shí),PGE2合成并釋放到胞外。前列腺素E2受體(EP)是一類G蛋白偶聯(lián)受體,PGE2的作用依賴于細(xì)胞上表達(dá)的具有不同功能的PGE2受體EP亞型的激活。
研究發(fā)現(xiàn)EP在機(jī)體幾乎所有系統(tǒng),如心血管系統(tǒng)、呼吸系統(tǒng)、生殖系統(tǒng)、神經(jīng)系統(tǒng)等等,在多種疾病的發(fā)生中發(fā)揮作用。在新年來(lái)臨之際,艾美捷為您整理準(zhǔn)備了全面的EP研究體系的工具。從抗體、抑制劑到活性分析試劑盒,滿足您的一切需求。
EP抗體匯總
(J CLIN INVEST、Cancer Res等雜志有過(guò)引用喲~)
| 名稱 | 貨號(hào) | 適應(yīng)性 | 詳情 |
| Anti-Prostanoid EP1 Receptor (extracellular) | APR-063 | IC, LCI, WB(IFC, IH, IP) | 詳情 |
| Anti-Prostanoid EP2 Receptor (extracellular) | APR-064 | IFC, IH, WB(IC, IP, LCI) | 詳情 |
| Anti-Prostanoid EP3 Receptor | APR-065 | WB(IC, IFC, IH, IP) | 詳情 |
| EP1 Receptor Polyclonal Antibody | 101740 | ICC and WB | 詳情 |
| EP2 Receptor Polyclonal PE Antibody | 10477 | FC、ICC | 詳情 |
| EP2 Receptor Polyclonal Antibody | 101750 | ICC 、WB | 詳情 |
| EP3 Receptor Polyclonal Antibody | 101760 | ICC and WB | 詳情 |
| EP4 Receptor (C-Term) Polyclonal Antibody | 101775 | ICC, IHC, and WB | 詳情 |
| EP4 Receptor (N-Term) Polyclonal Antiserum | 101770 | WB | 詳情 |
| EP4 Receptor (C-Term) Polyclonal PE Antibody | 10479 | FC、IF | 詳情 |
| Anti-EP4 Receptor (C-Term):SureLight® APC | 16625 | FC ,cell-based assays | 詳情 |
| Prostaglandin E Synthase (cytosolic) Monoclonal Antibody | 18219 | WB,IP,ELISA | 詳情 |

Expression of Prostanoid EP1 Receptor in human U-87 MG cells
Immunocytochemical staining of live intact human glioblastoma U-87 MG cells. A. Extracellular staining of cells with Anti-Prostanoid EP1 Receptor (extracellular) antibody (#APR-063), (1:50) followed by goat anti-rabbit-AlexaFluor-594 secondary antibody (red). B. Live image of the cells. C. Merge of A and B.

Western blot analysis of rat brain lysate (lanes 1 and 4), rat stomach lysate (lanes 2 and 5) and mouse kidney lysate (lanes 3 and 6):
1-3. Anti-Prostanoid EP2 Receptor (extracellular) antibody (#APR-064), (1:500).
4-6. Anti-Prostanoid EP2 Receptor (extracellular) antibody, preincubated with the control peptide antigen

Expression of Prostanoid EP2 Receptor in rat cerebellum
Immunohistochemical staining of perfusion-fixed frozen rat brain sections using Anti-Prostanoid EP2 Receptor (extracellular) antibody (#APR-064), (1:100). Prostanoid EP2 Receptor staining (red) is detected inPurkinje neurons and their dendritic tree (arrow). Blue is DAPI nissl counterstain.
EP活性檢測(cè)試劑盒類
(檢測(cè)靈敏度高,重復(fù)性好,Cancer Res等雜志有過(guò)引用喲~)
| 名稱 | 貨號(hào) | 適應(yīng)性 | 詳情 |
| EP2 Receptor (rat) Reporter Assay Kit | 600340 | rat EP2 receptor | 詳情 |
| EP4 Receptor (rat) Reporter Assay Kit | 600350 | rat EP4 receptor | 詳情 |
| EP4 Receptor (rat) Activation Assay Kit (cAMP) | 600410 | EP4 receptor agonists screening | 詳情 |

EP拮抗劑類
| 名稱 | 貨號(hào) | 適應(yīng)性 | 劑量 | 詳情 |
| SC-51322 | 10010744 | EP1 antagonist | ED50 = 0.9 mg/kg (mouse) | 詳情 |
| SC-51089 | 10011561 | EP1 antagonist | ED50 = 6.3 mg/kg(mice) | 詳情 |
| AH 6809 | 14050 | EP and DP receptor | EC50 of about 5 x 10−5 M | |
| Misoprostol | 13821 | EP2, EP3 and EP4 antagonist | EC50 = 0.35 µM(human neutrophils) | 詳情 |
好了,EP研究工具就暫時(shí)整理到這里,另附上PGE2的ELISA試劑盒相關(guān)介紹(PGE2 ELISA),拿走不謝喲~
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