什么是S100B？
       S100家族蛋白是一組低分子量的鈣結(jié)合蛋白，因其可溶解在pH值為7.0的飽和硫酸銨溶液中，故命名為S100蛋白，由α和β兩種亞基組成，形成同型或者異型二聚體，主要分為三個亞型：S100A0（αα）、S100A(αβ) 和 S100B(ββ)。不同S100蛋白亞型在人體的表達分布具有相對特異性，其中S100A0主要存在于神經(jīng)元細胞中；S100A主要存在于橫紋肌、心肌和腎臟；S100B主要分布于中樞神經(jīng)系統(tǒng)和周圍神經(jīng)系統(tǒng)的神經(jīng)膠質(zhì)細胞和Schwann細胞以及某些神經(jīng)元細胞、黑色素細胞、軟骨細胞和脂肪細胞中。
S100B是目前在惡性黑色素瘤中應(yīng)用最廣泛的生物標(biāo)志分子，特別是轉(zhuǎn)移性黑色素瘤，S100B水平的升高與預(yù)后相關(guān)，升高的血清S100B水平強烈提示預(yù)后不良。亦有報道稱，血清標(biāo)志物 S100B 檢測可準(zhǔn)確識別肺癌腦轉(zhuǎn)移。

Abnova艾美捷全國代理商熱線

       有沒有可以檢測S100B含量的試劑盒呢？
       艾美捷科技為您推薦享譽全球市場的S100B定量分析試劑盒： KA0037

       原理：該S100B定量分析試劑盒利用雙抗夾心法，在96孔板中預(yù)包被了人S100B蛋白的捕獲抗體，將標(biāo)準(zhǔn)品，質(zhì)控品，以及樣品加入到96孔板中孵育結(jié)合，經(jīng)過洗滌，再加入生物素標(biāo)記的S100B檢測抗體，通過鏈霉親和素-HRP系統(tǒng)結(jié)合再次放大信號，HRP與底物反應(yīng)產(chǎn)生有色產(chǎn)物。吸光值越高，對應(yīng)樣品中S100B含量越多。

       S100B ELISA試劑盒Tips：
       »適用樣品：脊髓液（CSF），血清，肝素血漿（EDTA和檸檬酸鈉血漿，不能用于該試劑盒）
       »檢測范圍：10 to 320 pg/mL

《 S100B ELISA試劑盒標(biāo)準(zhǔn)曲線 》

 
       S100B ELISA試劑盒已發(fā)布眾多文章：
       1.BET bromodomain inhibitors synergize with ATR inhibitors in melanoma in melanoma.
Muralidharan SV, Einarsdottir BO, Bhadury J, Lindberg MF, Wu J, Campeau E, Bagge RO, Stierner U, Ny L, Nilsson LM, Nilsson JA.Cell Death Dis. 2017 Aug 10;8(8):e2982.
       2.S100B promotes injury-induced vascular remodeling through modulating smooth muscle phenotype.
Cao T, Zhang L, Yao LL, Zheng F, Wang L, Yang JY, Guo LY, Li XY, Yan YW, Pan YM, Jiang M, Chen L, Tang JM, Chen SY, Jia-NingWang.Biochim Biophys Acta. 2017 Jul 7. [Epub ahead of print]
       3.Inflammation and vascular remodeling in the ventral hippocampus contributes to vulnerability to stress.
Pearson-Leary J, Eacret D, Chen R, Takano H, Nicholas B, Bhatnagar S.Transl Psychiatry. 2017 Jun 27;7(6):e1160.
       4.Fast therapeutic hypothermia prevents post-cardiac arrest syndrome through cyclophilin D-mediated mitochondrial permeability transition inhibition.
Jahandiez V, Cour M, Bochaton T, Abrial M, Loufouat J, Gharib A, Varennes A, Ovize M, Argaud L.Basic Res Cardiol. 2017 Jul;112(4):35. doi: 10.1007/s00395-017-0624-3. Epub 2017 May 10.
       5.Effect of Exercise Intensity on Neurotrophic Factors and Blood-Brain Barrier Permeability Induced by Oxidative-Nitrosative Stress in Male College Students.
Roh HT, Cho SY, Yoon HG, So WY.Int J Sport Nutr Exerc Metab. 2016 Dec 20:1-23.
       6.Soluble TLR2 and 4 concentrations in cerebrospinal fluid in HIV/SIV-related neuropathological conditions.
Mothapo KM, Ten Oever J, Koopmans P, Stelma FF, Burm S, Bajramovic J, Verbeek MM, Rikkert MG, Netea MG, Koopman G, van der Ven AJJ Neurovirol. 2016 Nov 23. [Epub ahead of print]
       7.The effects of aerobic exercise training on oxidant-antioxidant balance, neurotrophic factor levels, and blood-brain barrier function in obese and nonobese men.
Roh HT,So WYJournal of Sport and Health Science. 2016 Jul 18
       8.Obesity promotes oxidative stress and exacerbates blood-brain barrier disruption after high-intensity exercise.
Roh H, Cho S, So W.Journal of Sport and Health Science. 2016 Jun 27. [Epub ahead of print]
       9.Cognitive Function and Oxidative Stress After Carotid Endarterectomy: Comparison of Propofol to Sevoflurane Anesthesia.
Kalimeris K, Kouni S, Kostopanagiotou G, Nomikos T, Fragopoulou E, Kakisis J, Vasdekis S, Matsota P, Pandazi AJ Cardiothorac Vasc Anesth. 2013 May 29. pii: S1053-0770(12)00640-4. doi: 10.1053/j.jvca.2012.12.009.
       10.The prognostic significance of the serum biomarker H-FABP in comparison with S100b in severe traumatic brain injury.
Walder B, Robin X, Rebetez MM, Copin JC, Gasche Y, Sanchez JC, Turck NJ Neurotrauma. 2013 Apr 16.
       11.Induction of Oxidative and Nitrosative damage leads to Cerebrovascular Inflammation in Animal Model of Mild Traumatic Brain Injury Induced by Primary Blast.
Abdul-Muneer PM, Schuetz H, Wang F, Skotak M, Jones J, Gorantla S, Zimmerman MC, Chandra N, Haorah JFree Radic Biol Med. 2013 Mar 2. pii: S0891-5849(13)00093-2. doi: 10.1016/j.freeradbiomed.2013.02.029.
       12.Remote ischemic preconditioning in cyanosed neonates undergoing cardiopulmonary bypass: A randomized controlled trial.
Jones BO, Pepe S, Sheeran FL, Donath S, Hardy P, Shekerdemian L, Penny DJ, McKenzie I, Horton S, Brizard CPJ Thorac Cardiovasc Surg. 2013 Feb 13. pii: S0022-5223(13)00026-3. doi: 10.1016/j.jtcvs.2013.01.003.
13.Marked Increase of the Astrocytic Marker S100B in the Cerebrospinal Fluid of HIV-infected Patients on LPV/r-Monotherapy.
Pasquier RA, Jilek S, Kalubi M, Yerly S, Fux CA, Gutmann C, Cusini A, Gunthard HF, Cavassini M, Vernazza PL; the Swiss HIV Cohort Study.AIDS. 2012 Oct 1. [Epub ahead of print]
       14.S100B: Role in cardiac remodeling and function following myocardial infarction in diabetes.
Mohammadzadeh F, Desjardins JF, Tsoporis JN, Proteau G, Leong-Poi H, Parker TG.Life Sci. 2012 Sep 20. pii: S0024-3205(12)00510-3. doi: 10.1016/j.lfs.2012.09.011. [Epub ahead of print]
       15.Plasma heart-type fatty acid binding protein level in acute ischemic stroke: Comparative analysis with plasma S100B level for diagnosis of stroke and prediction of long-term clinical outcome.
Park SY, Kim MH, Kim OJ, Ahn HJ, Song JY, Jeong JY, Oh SH.Clin Neurol Neurosurg. 2012 Jul 3.
Hyperglycaemia-induced pro-inflammatory responses by retinal Muller glia are regulated by the receptor for advanced glycation end-products (RAGE).
Zong H, Ward M, Madden A, Yong PH, Limb GA, Curtis TM, Stitt AW.Diabetologia. 2010 Sep 12. [Epub ahead of print]
       16.Relative quantification of proteins in human cerebrospinal fluids by MS/MS using 6-plex isobaric tags.
Dayon L, Hainard A, Licker V, Turck N, Kuhn K, Hochstrasser DF, Burkhard PR, Sanchez JC.Anal Chem. 2008 Apr 15;80(8):2921-31. Epub 2008 Mar 1.

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