CDKN3 is a member of the dual specificity protein phosphatase family that acts as a cyclin-dependent kinase inhibitor (1). CDKN3 has been shown to interact with and dephosphorylate specifically the CDK2 kinase thereby preventing it’s activation. CDKN3 has been reported to be deleted, mutated, or overexpressed in several kinds of cancers. Increased expression of CDKN3 leads to increased levels of kinase-associated phosphatase activity that inhibits the G(1)/S transition of the cell cycle by dephosphorylating the cyclin-dependent kinases (2). CDKN3 Protein is ideal for investigators involved in Signaling Proteins, Cell Cycle Proteins, Cancer, Cell Cycle, and Ser/Thr Kinases research.
序列
該【干冰】CDKN3 recombinant protein-GST fusion protein - 009-001-R70的詳細信息查看Rockland提供的產品說明書。
來源宿主
該【干冰】CDKN3 recombinant protein-GST fusion protein - 009-001-R70的詳細信息查看Rockland提供的產品說明書。
溶解建議
該【干冰】CDKN3 recombinant protein-GST fusion protein - 009-001-R70的詳細信息查看Rockland提供的產品說明書。
保存建議
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
