MO25α (mouse protein 25 alpha) is a 40-kDa protein that interacts with the STE20-related adaptor-alpha (STRADα) pseudo kinase to form a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase (1). LKB1 plays a critical role in cell proliferation, polarity and energy metabolism. LKB1 is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25α binds directly to a conserved Trp-Glu-Phe sequence at the STRADα C terminus, and markedly enhances the binding of STRADα to LKB1 thereby increasing LKB1 catalytic activity (2). MO25α Protein is ideal for investigators involved in Signaling Proteins, Cellular Proteins, Cardiovascular Disease, and Metabolic Disorder research.
序列
該【干冰】MO25 alpha recombinant protein-GST fusion protein - 009-001-S49的詳細信息查看Rockland提供的產品說明書。
來源宿主
該【干冰】MO25 alpha recombinant protein-GST fusion protein - 009-001-S49的詳細信息查看Rockland提供的產品說明書。
溶解建議
該【干冰】MO25 alpha recombinant protein-GST fusion protein - 009-001-S49的詳細信息查看Rockland提供的產品說明書。
保存建議
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
