Moesin (or membrane-organizing extension spike protein) belongs to ERM family that modulates epithelial integrity by regulating cell-signalling events that affect actin organization and polarity (1). The effects of Moesin on epithelial cells appear to result from inhibition of Rho signaling. ERM proteins serve a structural role in linkage of the cytoskeletion to the plasma membrane and the rescue of cells lacking Moesin by modulation of Rho signaling indicates that inhibition of Rho activity may be a more critical function of Moesin. The negative feedback loop produced by Rho's activation of ERM may be an important mechanism that prevents the excessive migratory and invasive properties characteristic of metastatic cancer cells (2). Moesin Protein is ideal for investigators involved in Signaling Reagents, Protein Substrates, Inflammation, and PKA/PKC Pathway research.
序列
該【干冰】Moesin recombinant protein-GST fusion protein - 009-001-S50的詳細信息查看Rockland提供的產品說明書。
來源宿主
該【干冰】Moesin recombinant protein-GST fusion protein - 009-001-S50的詳細信息查看Rockland提供的產品說明書。
溶解建議
該【干冰】Moesin recombinant protein-GST fusion protein - 009-001-S50的詳細信息查看Rockland提供的產品說明書。
保存建議
Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
