Cdk1 (cyclin-dependent kinase 1), also known as p34Cdc2 (cell division control protein kinase 2) depends on cyclin A and B and is triggered by a positive feedback loop at the end of G2 phase, which is the key event that initiates mitotic entry. Destruction of cyclin B during metaphase results in inactivation of Cdk1, allowing mitotic exit and cell division. Cdk1 also contributes to the control of DNA replication. Cdk1 can be ihibited by several transcriptional targets of p53, such as p21WAF.
應用類型
IP, WB, IHC(P), ICC
免疫原
Bacterially expressed full-length human Cdk1 protein
來源宿主
小鼠
反應性
Cow, Non-human primates, Human
保存建議
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
