CD300a (CMRF-35H, IRp60) is a non-MHC-specific inhibitory receptor of immunoglobulin superfamily, which contains three immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that associate with SH2-containing phosphatases SHP-1 and SHP-2. CD300a is expressed on many cell types including T cells, NK cells, neutrophils, eosinophils or mast cells. Its triggering inhibits activating signals such as those of IL5, GM-CSF or eotaxin, as well as supresses mast cell degranulation or NK cell cytotoxic activity.
應用類型
FC (QC tested), WB
免疫原
HPB human acute lymphoid leukemia cell line
來源宿主
小鼠
反應性
Human
保存建議
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
