The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization; the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.
應用類型
WB, ICC
免疫原
Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.
來源宿主
小鼠
反應性
Mouse, Human
保存建議
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
