SHIP-1 (SH2 domain containing inositol phosphatase-1) is a 5′inositol phosphatase that regulates cell responses in lymphocytes and myeloid cells by hydrolyzing the second messenger PI(3,4,5) trisphosphate. SHIP-1 is recruited upon engagement of both inhibitory and activatory receptors, such as FcgammaRIIB, Fcgamma RIII, FcepsilonRI or cytokine and growth factor receptors, and supresses PI3K-dependent signaling, down-regulates cell migration and invasion of transformed cells and phagocytosis. SHIP-1 also serves as a scaffold for the recruitment of other proteins to the plasma membrane.
應用類型
FC, WB
免疫原
Peptide coresponding to a sequence within N-terminal domain of Human SHIP-1.
來源宿主
小鼠
反應性
Human
保存建議
Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
