【干冰】Anti-GABA(A) Receptor gamma 2 (Rabbit) Antibody - 112-401-C81-【干冰】Anti-GABA(A) Receptor gamma 2 (Rabbit) Antibody

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背景資料: Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl? channel associated with the GABAA receptor (GABAA-R) sub-type. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six αs, four βs and four γs, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for α- and β-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a γ-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different α-subunits of the receptor. Phosphorylation of β-subunits of the receptor has been shown to modulate GABAA-R function. Anti-GABA(A) Receptor gamma 2 antibody is ideal for investigators involved in Neuroscience.

免疫原: Anti-GABA(A) Receptor gamma 2 Antibody was produced by repeated immunizations with rat GABA(A) Receptor gamma 2- Synthetic peptide corresponding to amino acid residues specific to the gamma 2 subunit.

保存建議: Store vial at -20° C prior to opening.? This product is stable at 4° C as an undiluted liquid.? For extended storage, aliquot contents and freeze at -20° C or below.? Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。