中文名稱

重組人復制起始識別復合體ORC-1 BAH結構域（25ug）

英文名字

ORC1 BAH domain (human recombinant)

供應商

Cayman Chemical

產品貨號

11919-25

產品報價

￥已停產

產品說明書

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購買方式

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產品新聞

背景資料

ORC1, a component of the Origin Recognition Complex, is necessary for the initiation of DNA replication. It is bound in complex with ORC2, ORC3, ORC4, ORC5, and ORC6. The BromoAdjacent Homology (BAH) domain of ORC1 recognizes histone 4 dimethylated at lysine 20, which is enriched at replication origins (ORI).{21060} Chromatin immunoprecipitation and parallel sequencing of ORC1 DNA binding sites has been used to identify the ORI sites in HeLa cells.{25191} In addition to BAH mediated nucleosome recognition, ORC1 contains ATPase activity which is required for loading the minichromosome maintenance helicase complex.{25192} ORC1 levels oscillate during the cell cycle, decreasing during S phase following formation of pre-replication complexes.{25194} Mutations in ORC1 have been shown to cause Meier-Gorlin syndrome, a form of primordial dwarfism.{25193} This protein product contains the BAH domain region of ORC1.

產品描述

提供的重組人復制起始識別復合體ORC-1 BAH結構域（25ug）產品形式為：20 mM Tris, pH 8.0, containing 50 mM sodium chloride and 20% glycerol.

產品形式

ORC1, a component of the Origin Recognition Complex, is necessary for the initiation of DNA replication. It is bound in complex with ORC2, ORC3, ORC4, ORC5, and ORC6. The BromoAdjacent Homology (BAH) domain of ORC1 recognizes histone 4 dimethylated at lysine 20, which is enriched at replication origins (ORI).{21060} Chromatin immunoprecipitation and parallel sequencing of ORC1 DNA binding sites has been used to identify the ORI sites in HeLa cells.{25191} In addition to BAH mediated nucleosome recognition, ORC1 contains ATPase activity which is required for loading the minichromosome maintenance helicase complex.{25192} ORC1 levels oscillate during the cell cycle, decreasing during S phase following formation of pre-replication complexes.{25194} Mutations in ORC1 have been shown to cause Meier-Gorlin syndrome, a form of primordial dwarfism.{25193} This protein product contains the BAH domain region of ORC1.

保存建議

建議您在收到Cayman Chemical品牌的重組人復制起始識別復合體ORC-1 BAH結構域（25ug）產品后置于-80度保存，產品有效期為180天.

其他

Cayman Chemical向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產品以及客戶訂制化服務.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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