G?6976 is an ATP-competitive PKC inhibitor specific for Ca2+-dependent PKCalpha (IC50= 2.3nM) and PKCBeta1 (IC50 = 6.2nM) isozymes (1). It is also a potent inhibitor of PKD (IC50= 20nM) (2). Researchers have demonstrated that G?6976 blocks JNK activation (3-5) and inhibits PKCalpha-mediated, TPA-stimulated phosphorylation of CREB at Ser133 (6,7). G?6976 is also an effective inhibitor of the tyrosine kinases Jak2 and FLT3 (8), as well as TrkA and TrkB (9).Solubility:~25mg/ml (DMSO).Storage and Stability:Lyophilized powder may be stored at -20°C. Stable for 6 months. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
產品形式
該產品為凍干粉形式，緩沖液為：DSMO。
保存建議
接收到G?6976 (ATP-competitive PKC Inhibitor Specific for Ca2+-dependent PKCalpha and PKCBeta1)產品后，置于-20°C溫度下保存。
