- 中文名稱
重組人ECT2 BRCT結構域（25ug）
- 英文名字
- ECT2 BRCT domains (human recombinant)
- 供應商
- Cayman Chemical
- 產品貨號
- 14168-25
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.
- 產品新聞
- 背景資料
- Epithelial cell-transforming sequence 2 oncogene (ECT2) is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP from small GTPases of the Rho family, such as RhoA, RhoC, Rac1, and Cdc42.{24795} ECT2 GEF activity plays an essential role during cytokinesis.{24792} ECT2 contains a DH (DBL-homology) domain, a pleckstrin homology (PH) domain and tandem BRCT domains.{24794} BRCT domains are modular units of ~100 amino acids that fold independently and recognize linear phosphoserine or phosphothreonine regions to mediate protein-protein and protein-DNA interactions.{23632,22097} BRCT domains were initially recognized in the C-terminal region of the breast cancer protein BRCA1, as well as the p53 binding protein and the yeast cell cycle checkpoint protein RAD9.{23633} BRCT domains often occur as tandem repeats at the C-terminal end of several proteins that are functionally diverse.{22097} Most BRCT domain-containing proteins participate in DNA-damage checkpoint control or DNA-repair pathways, or both.{23634,23633} The BRCT domains of ECT2 make intramolecular interactions with the C-terminal DH/PH domains of the protein, thus, masking the catalytic GEF activity for Rho GTPases.{24796} Additionally, release of the autoinhibition by the BRCT domains may be necessary for the proper functioning of ECT2 during cytokinesis.{24796} Expression levels of ECT have been shown to be strongly correlated with prognosis in glioma patients.{24793}
- 產品描述
- 提供的重組人ECT2 BRCT結構域（25ug）產品形式為：50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
- 產品形式
- Epithelial cell-transforming sequence 2 oncogene (ECT2) is a guanine nucleotide exchange factor (GEF) that catalyzes the exchange of GDP for GTP from small GTPases of the Rho family, such as RhoA, RhoC, Rac1, and Cdc42.{24795} ECT2 GEF activity plays an essential role during cytokinesis.{24792} ECT2 contains a DH (DBL-homology) domain, a pleckstrin homology (PH) domain and tandem BRCT domains.{24794} BRCT domains are modular units of ~100 amino acids that fold independently and recognize linear phosphoserine or phosphothreonine regions to mediate protein-protein and protein-DNA interactions.{23632,22097} BRCT domains were initially recognized in the C-terminal region of the breast cancer protein BRCA1, as well as the p53 binding protein and the yeast cell cycle checkpoint protein RAD9.{23633} BRCT domains often occur as tandem repeats at the C-terminal end of several proteins that are functionally diverse.{22097} Most BRCT domain-containing proteins participate in DNA-damage checkpoint control or DNA-repair pathways, or both.{23634,23633} The BRCT domains of ECT2 make intramolecular interactions with the C-terminal DH/PH domains of the protein, thus, masking the catalytic GEF activity for Rho GTPases.{24796} Additionally, release of the autoinhibition by the BRCT domains may be necessary for the proper functioning of ECT2 during cytokinesis.{24796} Expression levels of ECT have been shown to be strongly correlated with prognosis in glioma patients.{24793}
- 保存建議
- 建議您在收到Cayman Chemical品牌的重組人ECT2 BRCT結構域（25ug）產品后置于-80度保存，產品有效期為365天.
- 其他
- Cayman Chemical向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產品以及客戶訂制化服務.
- 注意
-
該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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