中文名稱

重組人真核起始因子4E（50ug）

英文名字

eIF4E (human recombinant)

供應商

Cayman Chemical

產品貨號

15137-50

產品報價

￥已停產

產品說明書

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購買方式

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產品新聞

背景資料

Eukaryotic translation is a complex biochemical process requiring several initiation factors. The first step in the initiation of mRNA translation involves binding of the small ribosomal subunit to mRNA.{25365} The central component in the recruitment of the pre-initiation complex during translation is the eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4A, eIF4E, and eIF4G1/eIF4G3.{25357} The 5’-terminal end of eukaryotic mRNA has a common cap structure that is important for stabilizing mRNA and ribosome binding.{25366} The eIF4E component binds specifically to the mRNA cap structure to initiate protein synthesis by recognizing methyl-7-guanosine.{25357,25363} eIFA is a DEAD-box helicase, responsible for unwinding the mRNA, while eIF4G acts as a scaffold protein with binding sites for the poly(A)-binding protein and eIF3. eIF4G also possesses central and C-terminal eIF4A binding sites and a C-terminal binding site for the protein kinase Mnk1 (mitogen-activated protein kinase-interacting kinase).{25364} Mnk1 phosphorylates eIF4E at Ser209, which is believed to be essential for eIF4E’s oncogenic potential.{25361,25359,25360} Further, overexpression of eIF4e is seen in many human malignancies, including breast, colon, head and neck carcinomas, and others.{25358,25362}

產品描述

提供的重組人真核起始因子4E（50ug）產品形式為：20 mM sodium phosphate, pH 7.3, containing 100 mM sodium chloride, 100 μM TCEP, and 20% glycerol.

產品形式

Eukaryotic translation is a complex biochemical process requiring several initiation factors. The first step in the initiation of mRNA translation involves binding of the small ribosomal subunit to mRNA.{25365} The central component in the recruitment of the pre-initiation complex during translation is the eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4A, eIF4E, and eIF4G1/eIF4G3.{25357} The 5??-terminal end of eukaryotic mRNA has a common cap structure that is important for stabilizing mRNA and ribosome binding.{25366} The eIF4E component binds specifically to the mRNA cap structure to initiate protein synthesis by recognizing methyl-7-guanosine.{25357,25363} eIFA is a DEAD-box helicase, responsible for unwinding the mRNA, while eIF4G acts as a scaffold protein with binding sites for the poly(A)-binding protein and eIF3. eIF4G also possesses central and C-terminal eIF4A binding sites and a C-terminal binding site for the protein kinase Mnk1 (mitogen-activated protein kinase-interacting kinase).{25364} Mnk1 phosphorylates eIF4E at Ser209, which is believed to be essential for eIF4E??s oncogenic potential.{25361,25359,25360} Further, overexpression of eIF4e is seen in many human malignancies, including breast, colon, head and neck carcinomas, and others.{25358,25362}

保存建議

建議您在收到Cayman Chemical品牌的重組人真核起始因子4E（50ug）產品后置于-80度保存，產品有效期為180天.

其他

Cayman Chemical向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產品以及客戶訂制化服務.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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