中文名稱

NSC 25953 |二硫化四乙基秋蘭姆；N，N，N'，N'-四乙基-硫代過氧二碳酸二酰胺

英文名字

NSC 25953|Tetraethylthiuram disulfide; N,N,N',N'-tetraethyl-thioperoxydicarbonic diamide

供應商

Cayman Chemical

產品貨號

15303-50

產品報價

￥已停產

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868

產品新聞

背景資料

Disulfiram is a copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence.{25186} It also inhibits the copper-dependent enzyme dopamine β-hydroxylase, which prevents the breakdown of dopamine and has been considered as a treatment for cocaine dependence.{25185} When in complex with copper, disulfiram has been shown to inhibit purified 20S proteasome (IC50 = 7.5 μM) and 26S proteasome (IC50 = 20 μM) from MDA-MB-0231 breast cancer cells.{25183,25182} Because disulfiram targets the ubiquitin-proteasome pathway, it has been investigated as an anti-cancer agent. Furthermore, at 250 nM it has been shown to induce reactive oxygen species, to activate JNK and p38 pathways, and to inhibit NF-κB activity, which suppresses self-renewal in cancer stem cells.{25187,25184}

產品描述

A copper and zinc chelator and an irreversible inhibitor of aldehyde dehydrogenase (IC50 = 0.1 mM) that has been indicated for the treatment of alcohol dependence; targets the ubiquitin-proteasome pathway, induces ROS, activates JNK and p38 pathways, and inhibits NF-κB activity in cancer cells

產品形式

A crystalline solid

保存建議

建議您在收到Cayman Chemical品牌的Disulfiram (50 g)產品后置于-20度保存，產品有效期為730天.

其他

Cayman Chemical向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產品以及客戶訂制化服務.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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