中文名稱

重組人染色框同源物3（50ug）

英文名字

CBX3 (human recombinant)

供應商

Cayman Chemical

產品貨號

15467-50

產品報價

￥已停產

產品說明書

點擊查看

購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.

產品新聞

背景資料

The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1-α (CBX5), HP1-β (CBX1), and HP1-r (CBX3), are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain that connects the two.{23468} Extensive post-translational modifications have been observed and mapped on the CBX proteins.{23471} The chromodomain of CBX3 has been shown to recognize methylated histone H3 lysine 9, methylated histone H1 lysine 26, and G9A methylated at lysine 185.{25450} CBX3 associates with the exons of a subset of actively transcribed genes, and loss of CBX3 results in accumulation of unspliced mRNA from that subset of genes.{25452,25453} Further, CBX3 suppresses Nanog gene transcription in pre-induced pluripotent stem cells and long terminal repeat protein expression in HIV-1 infected cells.{25453,25449} Knockdown of CBX3 by siRNA in cells latently infected with HIV-1 leads to virus reactivation.{25448} CBX3 has been proposed to be a biomarker for tumor stem cells in osteosarcoma.{25451}

產品描述

提供的重組人染色框同源物3（50ug）產品形式為：50 mM Tris, pH 7.4, containing 150 mM sodium chloride and 20% glycerol.

產品形式

The heterochromatin protein 1 (HP1) family, which consists of isoforms HP1-?? (CBX5), HP1-?? (CBX1), and HP1-r (CBX3), are chromatin-associated proteins involved in gene regulation and heterochromatin formation.{20846} CBX proteins have an N-terminal chromodomain, a C-terminal chromoshadow domain, and a hinge domain that connects the two.{23468} Extensive post-translational modifications have been observed and mapped on the CBX proteins.{23471} The chromodomain of CBX3 has been shown to recognize methylated histone H3 lysine 9, methylated histone H1 lysine 26, and G9A methylated at lysine 185.{25450} CBX3 associates with the exons of a subset of actively transcribed genes, and loss of CBX3 results in accumulation of unspliced mRNA from that subset of genes.{25452,25453} Further, CBX3 suppresses Nanog gene transcription in pre-induced pluripotent stem cells and long terminal repeat protein expression in HIV-1 infected cells.{25453,25449} Knockdown of CBX3 by siRNA in cells latently infected with HIV-1 leads to virus reactivation.{25448} CBX3 has been proposed to be a biomarker for tumor stem cells in osteosarcoma.{25451}

保存建議

建議您在收到Cayman Chemical品牌的重組人染色框同源物3（50ug）產品后置于-80度保存，產品有效期為180天.

其他

Cayman Chemical向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產品以及客戶訂制化服務.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

分享到：