Oxaprozin is a non-steroidal anti-inflammatory drug that inhibits COX-1 and COX-2 in human synovial cells with IC50 values of 2.2 and 36 μM, respectively.{23288} It has been reported to inhibit thromboxane B2 (Item No. 19030) production in human platelets (IC50 = ~ 2 μM) and to inhibit prostaglandin E2 (Item No. 14010) production by human synovial cells stimulated with IL-1β (IC50 = ~ 20 μM).{23288} It demonstrates analgesic and anti-inflammatory activity in rodent models at doses of 70-100 mg/kg.{25154}
產品描述
A non-steroidal anti-inflammatory drug that inhibits COX-1 (IC50 = 2.2 μM) and COX-2 (IC50 = 36 μM) in human synovial cells; inhibits TXB2 production in human platelets (IC50 = ~ 2 μM) and PGE2 production by human synovial cells (IC50 = ~ 20 μM)
