中文名稱

重組人苯鄰二酚-O-甲基轉移酶（100ug）

英文名字

Catechol O-Methyltransferase (human recombinant)

供應商

Cayman Chemical

產品貨號

15563-100

產品報價

￥詢價/100ug

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868.

產品新聞

背景資料

Catechol-O-methyltransferase (COMT) plays an important role in normal brain function and has been implicated in human disorders, such as Parkinson's disease. Using S-adenosyl-L-methionine (SAM) as a methyl donor, COMT methylates catechol substrates, which include neurotransmitters, such as dopamine, norepinephrine, epinephrine, and catecholestrogens; ascorbic acid; and carcinogenic flavonoids.{26885} There are two classes of COMT, the soluble cytosolic form (S-COMT), and the rough endoplasmic reticulum membrane bound form (MB-COMT).{26887} Both forms are coded by a single gene using two separate promoters.{26887} Cayman’s COMT is the soluble S-COMT isoform and is composed of 221 amino acids, whereas MB-COMT has an additional 50 amino acid residues, including 21 hydrophobic amino acid residues that compose the membrane anchor region.{26884} While S-COMT is predominate in most tissues, MB-COMT is found in higher concentrations in the brain.{26888} A common variant in exon 4 of the COMT gene leads to a substitution of valine by methionine,Val158Met, which affects the stability of COMT and may diminish activity by 50% in the human brain. Since COMT is one of the primary regulators of prefrontal cortex dopamine levels, it plays an important role in cognition.{26886}

產品描述

提供的重組人苯鄰二酚-O-甲基轉移酶（100ug）產品形式為：50mM Tris-HCl, pH 8.0, containing 500 mM sodium chloride.

產品形式

Catechol-O-methyltransferase (COMT) plays an important role in normal brain function and has been implicated in human disorders, such as Parkinson's disease. Using S-adenosyl-L-methionine (SAM) as a methyl donor, COMT methylates catechol substrates, which include neurotransmitters, such as dopamine, norepinephrine, epinephrine, and catecholestrogens; ascorbic acid; and carcinogenic flavonoids.{26885} There are two classes of COMT, the soluble cytosolic form (S-COMT), and the rough endoplasmic reticulum membrane bound form (MB-COMT).{26887} Both forms are coded by a single gene using two separate promoters.{26887} Cayman??s COMT is the soluble S-COMT isoform and is composed of 221 amino acids, whereas MB-COMT has an additional 50 amino acid residues, including 21 hydrophobic amino acid residues that compose the membrane anchor region.{26884} While S-COMT is predominate in most tissues, MB-COMT is found in higher concentrations in the brain.{26888} A common variant in exon 4 of the COMT gene leads to a substitution of valine by methionine,Val158Met, which affects the stability of COMT and may diminish activity by 50% in the human brain. Since COMT is one of the primary regulators of prefrontal cortex dopamine levels, it plays an important role in cognition.{26886}

保存建議

建議您在收到Cayman Chemical品牌的重組人苯鄰二酚-O-甲基轉移酶（100ug）產品后置于-80度保存，產品有效期為180天.

其他

Cayman Chemical向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產品以及客戶訂制化服務.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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