中文名稱

Dipirona |美他唑；1-[（2,3-二氫-1,5-二甲基-3-氧代-2-苯基-1H-吡唑-4-基）甲氨基]-甲磺酸，鈉鹽

英文名字

Dipirona|Metamizol; 1-[(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]-methanesulfonic acid, monosodium salt

供應商

Cayman Chemical

產品貨號

15771-50

產品報價

￥詢價/50g

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868

產品新聞

背景資料

Metamizole (sodium salt) is a nonopioid prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine (MAA) and 4-aminoantipyrine (AA), which have analgesic and antipyretic effects.{25749} MAA has been shown to inhibit COX activity 8-9-fold more potently than AA (COX-1: IC50s = 2.6 and 20.8 μM, respectively, and COX-2: IC50s = 4.7 and 41.8 μM, respectively).{25748} These metabolites can be further acylated with arachidonic acid (Item No. 90010) to form compounds that can bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors at low micromolar concentrations.{25749,25750} Metamizole is associated with a risk of agranulocytosis and has been banned against using in clinical and pharmacological settings in the United States since 1977.{25751,25747}

產品描述

An analgesic and antipyretic prodrug that is rapidly hydrolyzed to the metabolites 4-methylaminoantipyrine and 4-aminoantipyrine, which both inhibit COX activity (COX-1: IC50s = 2.6 and 20.8 μM, respectively, and COX-2: IC50s = 4.7 and 41.8 μM, respectively); binds to CB1 and CB2 receptors and TRPV1 receptors at low micromolar concentrations when acylated with arachidonic acid

產品形式

A crystalline solid

保存建議

建議您在收到Cayman Chemical品牌的Metamizole (sodium salt) (50 g)產品后置于-20度保存，產品有效期為730天.

其他

Cayman Chemical向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產品以及客戶訂制化服務.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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