中文名稱

3-（2-氯苯基）-N-（4-氯苯基）-N，5-二甲基-4-異惡唑甲酰胺

英文名字

3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide

供應商

Cayman Chemical

產品貨號

16291-5

產品報價

￥詢價/5mg

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868

產品新聞

背景資料

TGR5 is a G protein-coupled receptor for bile acids that mediates energy balance, inflammation, and digestion.{24271} TGR5 Receptor Agonist is a synthetic small molecule activator of this bile acid receptor (pEC50 = 6.8-7.5) that is reported to improve glucagon-like peptide-1 (GLP-1) secretion by increasing intracellular cAMP levels via TGR5.{27533,27532} In a canine model, 1 mg/kg of this TGR5 receptor agonist co-administered with glucose has been shown to increase GLP-1 secretion, improving glucose disposal.{27533} This compound potently stimulates cAMP formation (EC50 = 2.3 pM) in HEK cells expressing TGR5, and has been used to investigate the signaling, trafficking, and regulation of TGR5 receptors in order to identify potentially useful therapeutics for metabolic disorders.{27534}

產品描述

A small molecule activator of a G protein-coupled bile acid receptor (pEC50 = 6.8-7.5) that is reported to improve GLP-1 secretion by increasing intracellular cAMP levels; used to investigate the signaling, trafficking, and regulation of TGR5 receptors in order to identify potentially useful therapeutics for metabolic disorders

產品形式

A crystalline solid

保存建議

建議您在收到Cayman Chemical品牌的TGR5 Receptor Agonist (5 mg)產品后置于-20度保存，產品有效期為730天.

其他

Cayman Chemical向全球科學工作者提供多研究領域的生化、免疫試劑和分析試劑盒，其產品被廣泛應用于腫瘤、氧化氮、神經學、凋亡、氧化性損傷、內分泌學等不同研究領域.Cayman Chemical可提供用于檢測的特色試劑盒，如：類花生酸類物質、游離的生物標志、環核苷、激素及氧化氮等；也提供多種高質量試劑，包括：類花生酸類物質、氧化氮試劑及許多相關脂質、脂肪酸、酶和抗體.作為Cayman Chemical在中國的區域總代理，艾美捷科技有限公司將為中國客戶提供最全面的Cayman Chemical產品以及客戶訂制化服務.

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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