Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4) and H3K9, resulting in transcriptional repression.{14724} Host LSD1 is also recruited by certain viruses to limit H3K9 methylation, which can repress viral genes necessary for infection.{28724} OG-L002 is a potent inhibitor of LSD1 (IC50 = 0.02 μM) that less effectively inhibits the monoamine oxidases A (MAO-A) and MAO-B (IC50s = 1.38 and 0.72 μM).{28724} It blocks the expression of immediate early (IE) genes of herpes simplex virus (HSV) in HeLa cells but not that of cellular control genes.{28724} OG-L002 also reduces the expression of human cytomegalovirus IE genes and adenovirus E1A gene in mammalian cells.{28724} It is effective in vivo, repressing HSV primary infection in mice and blocking HSV reactivation from latency in a mouse ganglion explant model.{28724}
產品描述
A potent inhibitor of LSD1 (IC50 = 0.02 μM) that less effectively inhibits MAO-A and MAO-B (IC50s = 1.38 and 0.72 μM); blocks the expression of IE genes of HSV and hCMV in mammalian cells; represses HSV primary infection in mice and blocks HSV reactivation from latency in a mouse ganglion explant model
