Cayman’s Renin Monoclonal Antibody (Clone 3G10) is directed against the full-length renin (human recombinant) protein (Item No. 10006217). Renin is an aspartyl protease of approximately 40 kDa produced in the kidney by juxtaglomerular cells of the macula densa.{12331} Renin converts angiotensinogen into angiotensin I, activating a major arm of renal sodium and volume auto-regulation. Native human renin is a glycoprotein derived from preprorenin by sequential cleavage. The first cleavage releases the signal peptide (amino acids 1-23), forming the prorenin (44 kDa). The second cleavage removes the propeptide (amino acid 24-66), forming the functional renin protein (40 kDa). This antibody detects both the active renin and prorenin.
