中文名稱

L-蘇式-二氫鞘氨醇（沙芬醇）

英文名字

L-threo-Dihydrosphingosine (Safingol)

供應商

Matreya

產品貨號

1807-25

產品報價

￥詢價/25mg

產品說明書

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購買方式

銀行轉賬、電匯、支票、現金,在線支付寶及網銀支付,或直接與我們電話聯系400-6800-868

產品新聞

背景資料

Safingol is a fully saturated, nonnatural analogue of sphingosine that has anticancer properties and is being investigated for its potential as an antitumor therapy. It has been shown to inhibit both protein kinase C (PKC) and sphingosine kinase. Safingol competitively interacts at the regulatory phorbol-binding domain of PKC, which is a kinase involved in tumorigenesis. Safingol has been shown to potentiate the effect of doxorubicin (DOX) in tumor-bearing animals.1 It has been reported that safingol is able to increase the activity of DOX and other chemotherapeutic agents, including mitomycin C, by generating the pro-apoptotic second messenger ceramide, even in tumor cell lines that were resistant to chemotherapy due to mutations.2 However, a study has recently claimed that safingol induces cell death of an exclusively autophagic character and lacking any of the hallmarks of apoptosis.3 Safingol inhibited the reactive oxygen intermediates (ROI) released from isolated neutrophils and phorbol ester-induced edema and neutrophil influx. Safingol also demonstrates anti-inflammatory activity. Safingol, like the natural sphinganine, is used as a biosynthetic precursor for all complex sphingolipids although the metabolism of the natural and the nonnatural compounds are different.4

產品描述

Activity: Protein Kinase C (PKC) and Sphingosine Kinase inhibitor|L-threo-Sphinganine, C18 chain

產品形式

該L-蘇式-二氫鞘氨醇（沙芬醇）產品為固體形式

保存建議

對于本產品，我們推薦使用-20℃藍冰低溫進行運輸。在您收到貨物后，我們建議在-20℃溫度下冷凍保存，溶解使用說明請參考本品說明書。

其他

Matreya LLC是一家脂質生化公司，致力于開發和制造高質量的脂質和生物化學品。Matreya在化學合成以及天然產物提取和純化方面經驗豐富，生產出的產品具有最佳純度。 Matreya產品線包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和維生素E異構體（生育酚和生育三烯酚）。專長是生產高純度鞘氨醇、神經酰胺、硫酸酯、神經節苷脂、酶抑制劑、生育酚和生育三烯酚。是全球提供脂質產品最全的供應商之一。產品涉及生物化學、制藥、微生物學、食品和農業等研究領域。

注意

該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。

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