D-蘇式PPMP-D-threo-PPMP代理/參數/廠家-標準品（生化）-艾美捷科技有限公司

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背景資料: This product is a glucosylceramide synthase inhibitor, an enzyme that is essential for the synthesis of a very large number of different glycolipids that are found in many organisms. PPMP has four possible isomers due to its two chiral centers (Dthreo, L-threo, D-erythro, and L-erythro). Due to PPMP’s ability to inhibit the joining of ceramides with carbohydrates there can be an accumulation of ceramide in the cells and this can lead to apoptosis. This process has been suggested as a treatment for cancer since the addition of agents that retard ceramide glucosylation, such as PPMP, have been shown to increase cytotoxicity in tumor cells.1 Cells that were incubated with PPMP have been shown to have a 50% decrease in the viral fusion of HIV-1, causing a reduction in the penetration of this virus into these cells.2 PPMP has been used to arrest the growth of the malarial causing parasite Plasmodium falciparum by inhibiting its very specific glucosylceramide synthase, an approach that has great potential for malarial chemotherapy.3 In addition to its stereochemistry, the acyl chain of PPMP has a very marked effect on the intensity of the inhibitory action of the molecule. Conduritol B epoxide (CBE), an inhibitor of beta-glucosidase, and PPMP, an inhibitor of glucosylceramide synthase, can be used to create a model of Gaucher disease.4

產品描述: Activity: glucosylceramide synthase inhibitor|D-threo-1-Phenyl-2-hexadecanoylamino-3-morpholino-1-propanol?HCl

其他: Matreya LLC是一家脂質生化公司，致力于開發和制造高質量的脂質和生物化學品。Matreya在化學合成以及天然產物提取和純化方面經驗豐富，生產出的產品具有最佳純度。 Matreya產品線包括一系列鞘脂、糖脂、鞘糖脂、脂肪酸和酯、甾醇和維生素E異構體（生育酚和生育三烯酚）。專長是生產高純度鞘氨醇、神經酰胺、硫酸酯、神經節苷脂、酶抑制劑、生育酚和生育三烯酚。是全球提供脂質產品最全的供應商之一。產品涉及生物化學、制藥、微生物學、食品和農業等研究領域。