- 中文名稱
Anti-alpha-Tubulin Biotin
- 英文名字
- Anti-alpha-Tubulin Biotin
- 供應商
- EXBIO
- 產品貨號
- 1B-250-C025
- 產品報價
- ￥已停產
- 產品說明書
- 點擊查看
- 購買方式
- 銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868。
- 產品新聞
- 背景資料
- The microtubules are intracellular dynamic polymers made up of evolutionarily conserved polymorphic alpha/beta-tubulin heterodimers and a large number of microtubule-associated proteins (MAPs). The microtubules consist of 13 protofilaments and have an outer diameter 25 nm. Microtubules have their intrinsic polarity; highly dynamic plus ends and less dynamic minus ends. Microtubules are required for vital processes in eukaryotic cells including mitosis, meiosis, maintenance of cell shape and intracellular transport. Microtubules are also necessary for movement of cells by means of flagella and cilia. In mammalian tissue culture cells microtubules have their minus ends anchored in microtubule organizing centers (MTOCs).The GTP (guanosintriphosphate) molecule is an essential for tubulin heterodimer to associate with other heterodimers to form microtubule. In vivo, microtubule dynamics vary considerably. Microtubule polymerization is reversible and a populations of microtubules in cells are on their minus ends either growing or shortening – this phenomenon is called dynamic instability of microtubules. On a practical level, microtubules can easily be stabilized by the addition of non-hydrolysable analogues of GTP (eg. GMPPCP) or more commonly by anti-cancer drugs such as Taxol. Taxol stabilizes microtubules at room temperature for many hours. Using limited proteolysis by enzymes both tubulin subunits can be divided into N-terminal and C-terminal structural domains. The alpha-tubulin (relative molecular weight around 50 kDa) is globular protein that exists in cells as part of soluble alpha/beta-tubulin dimer or it is polymerized into microtubules. In different species it is coded by multiple tubulin genes that form tubulin classes (in human 6 genes). Expressed tubulin genes are named tubulin isotypes. Some of the tubulin isotypes are expressed ubiquitously, while some have more restricted tissue expression.Alpha-tubulin is also subject of numerous post-translational modifications. Tubulin isotypes and their posttranslational modifications are responsible for multiple tubulin charge variants - tubulin isoforms. Heterogeneity of alpha-tubulin is concentrated in C-terminal structural domain.
- 應用類型
- WB, IHC(P), ICC
- 免疫原
- Fraction of tubulin purified from porcine brain by two cycles of polymerization - depolymerization.
- 來源宿主
- 小鼠
- 反應性
- Mouse, Pig, Human, Turkey, Eisenia, Paramecium, Nicotiana, Yeast
- 保存建議
- Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on the label.
- 其他
- EXBIO是捷克一家著名的生物試劑公司，專注于流式細胞術配套試劑的開發。自1990年成立以來，EXBIO公司研發和制造的抗體分銷全球。目前，EXBIO可提供超過4000種質優、價廉的研究和臨床應用抗體，涵蓋了血液學，免疫學，癌癥，干細胞和細胞生物學等領域，如：CD分子、細胞粘附分子、細胞骨架、凋亡、細胞信號傳導、腫瘤標志物、人血型、HLA、生殖等研究用抗體，涉及熒光染料如FITC、PE、PE-Cy5、PE-Cy7、APC、PerCP、PerCP-Cy5.5、Pacific Blue、Pacific Orange、Alexa Fluor 488、Alexa Fluor 647、Alexa Fluor 700、Biotin等多達13種，滿足客戶各類實驗需求。
- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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