Anti-人CD29 FITC(流式抗體)-Anti-Hu CD29 FITC代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 different alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.

保存建議: Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.

其他: EXBIO是捷克一家著名的生物試劑公司，專注于流式細胞術配套試劑的開發。自1990年成立以來，EXBIO公司研發和制造的抗體分銷全球。目前，EXBIO可提供超過4000種質優、價廉的研究和臨床應用抗體，涵蓋了血液學，免疫學，癌癥，干細胞和細胞生物學等領域，如：CD分子、細胞粘附分子、細胞骨架、凋亡、細胞信號傳導、腫瘤標志物、人血型、HLA、生殖等研究用抗體，涉及熒光染料如FITC、PE、PE-Cy5、PE-Cy7、APC、PerCP、PerCP-Cy5.5、Pacific Blue、Pacific Orange、Alexa Fluor 488、Alexa Fluor 647、Alexa Fluor 700、Biotin等多達13種，滿足客戶各類實驗需求。