【干冰】Anti-HER3 (RABBIT) Antibody - 200-401-205-【干冰】Anti-HER3 (RABBIT) Antibody - 200-401-205代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: HER3 antibody is ideal for western blotting, ELISA and IP. The human Epidermal Growth Factor Receptor (EGFR) family is a family of receptor tyrosine kinases consisting of 4 members: EGFR, HER2, HER3 and HER4.? These receptors are expressed on a wide variety of tissue types and have been implicated in many human cancers, including breast, gastric, colon and prostate.? Strong expression of both HER3 and HER2 (also known as p185neu) by tumor cells can be associated with poor outcome for patients.? The ligand for HER3 and HER4 is called Neu Differentiation Factor (NDF) or Heregulin.? In some instances, antibodies against these receptors prove effective in combination therapy regimens for treatment of the disease.? Signaling through the EGFR family involves the combinatorial dimerization of the four known family members and is mediated by at least 8 different hormones, including EGF and the heregulins.? Heregulin binding and tyrosine phosphorylation by HER3 or HER4 is enhanced in the presence of HER2.? Structurally the members of the EGFR family are 1210 to 1342 amino acids in length with approximately 650 amino acids of the extracellular domain being heavily glycosylated.? The extracellular domains show up to 70% sequence homology.

免疫原: Anti-HER3 whole rabbit serum was prepared by repeated immunizations with a HER3 fusion protein corresponding to amino acids 1283 to 1323 (40 amino acids) at the carboxy-terminus of human HER3.

保存建議: Store Anti-HER3 at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。