Anti-Rub1 (RABBIT) Antibody - 200-401-427-Anti-Rub1 (RABBIT) Antibody - 200-401-427代理/參數/廠家-一抗-艾美捷科技有限公司

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背景資料: Ubiquitin-like proteins fall into ?two classes: the first class, ubiquitin-like modifiers (UBL’s) function as modifiers in a manner analogous to that of ubiquitin.? Examples of UBL’s are SUMO, Rub1 (also called Nedd8), Apg12, and Hub1.? Proteins of the second class include parkin, RAD23, and DSK2, and are designated ubiquitin-domain proteins (UDP’s). These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other.? In contrast to UBL’s, UDP’s are not proteolytically processed or conjugated to other proteins.? Rub1, and the corresponding human homolog Nedd8, are activated by the E1 ubiquitin-activating enzyme UBA2, which forms isopeptide linkages between thioesters.? Nedd8 shows 80% homology to ubiquitin.? The best known targets of Rub1 modification are members of the cullin family.? Cullins are subunits of an E3-ubiquitin ligase complex called the Skp1/Cul1/Cdc53-F-box (SCF).? The SCF promotes transfer of ubiquitin from a ubiquitin conjugating enzyme (E2) to the target protein.? Rub1 modification may regulate SCF function or localization.

免疫原: Rub1 Antibody was prepared from rabbit serum after repeated immunizations with full-length recombinant yeast Rub1 protein.

保存建議: Store vial at 4° C prior to restoration.?? For extended storage aliquot contents and freeze at -20° C or below.? Avoid cycles of freezing and thawing.? Centrifuge product if not completely clear after standing at room temperature.? This product is stable for several weeks at 4° C as an undiluted liquid.? Dilute only prior to immediate use.

其他: Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。