- 中文名稱
Anti-Apg8 (RABBIT) Antibody - 200-401-439
- 英文名字
- Anti-Apg8 (RABBIT) Antibody - 200-401-439
- 供應商
- Rockland
- 產品貨號
- 200-401-439
- 產品報價
- ￥詢價/500ug
- 產品說明書
- 點擊查看
- 購買方式
- 90%產品中國有現貨庫存。銀行轉賬、電匯、支票、現金，在線支付寶及網銀支付，或直接與我們電話聯系400-6800-868
- 產品新聞
- 背景資料
- Anti-Atg8 antibody is an Ubiquitin-like protein (UBL) antibody. UBL proteins and antibodies fall into two classes: the first class, ubiquitin-like modifiers (UBLs) function as modifiers in a manner analogous to that of ubiquitin.? Examples of UBLs are SUMO, Rub1 (also called Nedd8), Apg8 and Apg12.? Proteins of the second class include parkin, RAD23 and DSK2, are designated ubiquitin-domain proteins (UDPs).? These proteins contain domains that are related to ubiquitin but are otherwise unrelated to each other.? In contrast to UBLs, UDPs are not conjugated to other proteins.? Apg8 is required for autophagy (intracellular bulk protein degradation) in yeast.? Starved yeast cells take up their own cytoplasm into vacuoles through autophagic bodies.?? Autophagic bodies form a double-membraned structure called the autophagosome, which subsequently fuses with the vacuole/lysosome. This process similar in mammals.? Two sets of genes, APG and AUT, have been identified with this process, and are responsible for two ubiquitin-like systems Apg12 and Apg8, respectively.? Apg12 is synthesized in its mature form and seems to have one target, Apg5.? Almost all Apg12 molecules are conjugated with Apg5.? Aut2/Apg4 processes the Apg8/Aut7 system at its carboxy-terminal region.? Apg8 exists in two forms, one is membrane bound through a phospholipid. Lipidation/activation of Apg8 is mediated by Apg7 and transferred to Apg3 and finally forms a conjugate with phosphatidyl-ethanolamine (PE). Apg4 cleaves Apg8–PE, releasing Apg8 from membrane.? Morphological studies show that Apg8 localizes on the membrane of intermediate structures of the autophagosome; this transient association seems to be essential for formation of the autophagosome. Both Apg12 and Apg8 are highly conserved, with apparent homologues in the worm, mammals and plants. In higher eukaryotes, Apg8 consists of a multigene family. Anti-ATG8 Antibody is useful for researcher interested in autophagy, Cell Biology, Microbiology and Signal Transduction research.
- 應用類型
- ELISA,Immunohistochemistry,Immunoprecipitation,Western Blot,
- 免疫原
- Rabbit Anti-Apg8 antibody was prepared from rabbit serum after repeated immunizations with recombinant yeast Apg8 protein.
- 來源宿主
- Rabbit
- 反應性
- Yeast
- 保存建議
- Store antibody at 4° C prior to restoration.?? For extended storage aliquot contents and freeze at -20° C or below.? Avoid cycles of freezing and thawing.? Centrifuge product if not completely clear after standing at room temperature.? This product is stable for several weeks at 4° C as an undiluted liquid.? Dilute only prior to immediate use.
- 其他
- Rockland成立于1962年，是一家老牌抗體原產企業，其位于美國費城郊區的農場保有近20種實驗動物。Rockland公司為生命科學領域提供豐富的、高質量的抗體，包括載脂蛋白、細胞周期/凋亡、細胞因子、細胞信號蛋白、酶類、細胞外基質、轉錄因子(NFkB)和泛素（Ubiquitin）等識別抗體，應用范圍包括Western blot、免疫組化、免疫熒光和ELISA等。另外，Rockland也生產特別齊全的二抗，包括純化、生物素、HRP/ALP、熒光標記二抗，應用十分廣泛。
- 注意
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該頁面的中文產品信息的翻譯，僅供參考。準確的產品信息請以廠家的英文說明書為準。下單前，請瀏覽說明書確認。
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