DR5 TRAILR2 antibody detects human DR5 TrailR2. Apoptosis induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB. Anti DR5 TRAILR2 is ideal for investigators involved in apoptosis and NF-kappa B research.
DR5 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the c-terminus of human DR5.
來源宿主
Rabbit
反應性
H. sapiens (Human)
保存建議
Store DR5 antibody at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
