PF-573228(10毫克)產品是PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC???= 4 nM). PF-573,228 inhibits FAK phosphorylation on Tyr(397) with an IC?? of 30-100 nM.? Displays 50 - 250-fold selectivity for FAK over other protein kinases. Blocks serum and fibronectin-directed migration and decreases focal adhesion turnover?in vitro.