Caspases play a key role in apoptosis. Similar as other caspases，caspase-2 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Caspase-2 mRNA is alternatively spliced. The larger mRNA species encoding a product of 435 amino acids is known as ICH-1L. The smaller mRNA species encoding a protein of 312 amino acids is named ICH-1S. Over expression of ICH-1L induces apoptosis，while over expression of ICH-1S suppresses Rat-1 cell death induced by serum deprivation.
應用類型
Western blotting （1-2 ug/ml）. However， the optimal conditions should be determined individually. Detects the full length and small subunit of caspase-2. In human samples， it also detects a 30 kDa intermeadiate fragment
免疫原
Synthetic peptide surrounding amino acid 417 of mouse caspase-2
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Caspase-2蛋白發生免疫反應.
保存建議
提供的Caspase-2抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該Caspase-2抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
