Bok （Bcl-2-related ovarian killer） is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology （BH） domains 1 and 2 and the transmembrane sequence，Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some （Mcl-1，BHRF1，and Bfl-1） but not other （Bcl-2，Bcl-xL，and Bcl-w） anti-apoptotic members. In addition，cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1，but not with Bcl-2，further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary，testis and uterus.
應用類型
Western blot analysis （0.5-4 ug/ml）.
免疫原
Synthetic peptide surrounding amino acid 44 of rat BOK
來源宿主
兔
反應性
經檢測驗證，可與小鼠、大鼠種屬來源的Bok蛋白發生免疫反應.
保存建議
提供的Bok抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有50%甘油， 1% BSA， 0.02%硫柳汞的PBS （pH 7.2）緩沖液中.請將該Bok抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
