Apoptosis can be induced by certain cytokines including TNF and Fas Ligand of the TNF super-family through their death domain （DD） containing receptors，TNFR1 and Fas. A member of the TNF receptor family was recently identified and designated DR4 （death receptor 4） and TRAIL-R1. The ligand for this novel death receptor has been identified and termed TRAIL. DR4 is expressed in most of the human tissues including spleen，peripheral blood leukocytes （PBLs），small intestine and thymus. Like TNFR1，Fas and DR3，DR4 mediates apoptosis and NFkB activation in many tissues and cells.
應用類型
Western blot analysis （0.5-4 ug/ml） and immunofluorescence. However， the optimal conditions should be determined individually. The antibody detects a 57 kDa mouse DR4 in Western blot analysis.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 454 of human DR4
來源宿主
兔
反應性
經檢測驗證，可與小鼠種屬來源的DR4蛋白發生免疫反應.
保存建議
提供的DR4抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該DR4抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
