DR5 is the DD containing receptor for TRAIL，Apo2，TRAIL-R2，TRICK2，or KILLER. DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. Like DR3 and TNFR1，DR5 mediate apoptosis by FADD dependent pathway. Over-expression of DR5 induces apoptosis and activates NFkB.
應用類型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects 60 kDa DR5 in samples of human and mouse origins
免疫原
Synthetic peptide corresponding to residues surrounding amino acid 372 of mouse DR5 precursor
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠種屬來源的DR5蛋白發生免疫反應.
保存建議
提供的DR5抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該DR5抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
