CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand （CD40L），a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation，antibody class switching，modulation of apoptosis in the germinal center through interaction with T cells expressing CD40L，and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells，CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6，a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually.
免疫原
Synthetic peptide corresponding to residues surrounding amino acids 261 of human CD40
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠、猴、豬種屬來源的CD40蛋白發生免疫反應.
保存建議
提供的CD40抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該CD40抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
