Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins，it has the conserved ER retention KDEL （Lys-Asp-Glu-Leu） sequence at its C-terminus. Calreticulin has also been detected in the nucleus and nuclear envelop. Recent studies suggest that this soluble ER protein has a multifunctional role as it appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. Studies also suggest its involvement in certain autoimmune diseases. Consistence with its multiple functions the calreticulin molecule appears to have a zonal character. The protein has both high and low affinity calcium binding sites.
應用類型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Other applications have not been tested.
免疫原
Calreticulin-Maltose binding fusion protein
來源宿主
小鼠
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Calreticulin蛋白發生免疫反應.
保存建議
提供的Calreticulin抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5 mg/ml BSA和0.01%硫柳汞的PBS緩沖液中.請將該Calreticulin抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
