cdc42/Rac belongs to the superfamily of small GTPases that are structurally linked to the proto-oncogene product p21ras and are important for the control of cell growth and differentiation as well as for intracellular organization. Cdc42/Rac is an important upstream regulator of the protein kinase cascade that controls the SAPK/JNK and p38 activity. Recent data also suggest that constitutive active forms of cdc42 can induce apoptosis through a mechanism requiring signaling through SAPK/JNK.
應用類型
Western blotting （0.5-4 ug/ml） and in Immunohistochemistry （10-20 ug/ml）. However， the optimal conditions should be determined individually. The antibody detects cdc42 of human， mouse， rat， and bovine origins.
免疫原
Synthetic peptides surrounding amino acid 144 of human cdc42
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠、牛種屬來源的cdc42/Rac蛋白發生免疫反應.
保存建議
提供的cdc42/Rac抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該cdc42/Rac抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
