Insulin receptor substrates （IRS） subtypes are responsible for several insulin related activities，such as glucose homeostasis，cell growth，cell transformation，apoptosis and insulin signal transduction. The balance between Ser/Thr phosphorylation of IRS has been demonstrated to be an important regulator of insulin signaling. IRS1 has also been shown to be constitutively activated in cancers such as breast cancer，Wilm’s tumors，and adrenal cortical carcinomas. Does not recognize IRS peptide NOT phosphorylated at Ser616 and will not recognize IRS peptide phosphorylated at Tyr183. Also does not react with riboflavin carrier protein which is known to have multiple phosphate groups.
應用類型
The antibody can be used for indirect ELISA and WB.
免疫原
Synthetic peptide phosphorylated at Ser 616 site
來源宿主
小鼠
反應性
經檢測驗證，可與人種屬來源的Phospho-IRS （Ser616）蛋白發生免疫反應.
保存建議
提供的Phospho-IRS （Ser616）抗體產品為100 ug 無色溶液，其濃度為1.0 mg/ml，溶解于包含有0.05% （W/V） 疊氮鈉的PBS緩沖液中.請將該Phospho-IRS （Ser616）抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
