AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. It appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5’-AMP rises in response to fuel limitation and/or hypoxia. AMPK alpha1，a member of the Ser/Thr protein kinase family，is a catalytic subunit of AMPK.
應用類型
The antibody can be used for ELISA （0.25 ug/ml） and Western blotting （0.5 – 2.5 ug/ml）.
免疫原
Synthetic peptide selected from the C-terminal region of human AMPK alpha 1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠種屬來源的AMPK?1蛋白發生免疫反應.
保存建議
提供的AMPK?1抗體產品為100 ug 無色溶液，其濃度為0.25 mg/ml，溶解于包含有0.09% （W/V） 疊氮鈉的PBS緩沖液中.請將該AMPK?1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
