STATs （signal transducers and activators of transcription） are a family of cytoplamic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signalling peptides including cytokines，interferons，and growth factors. After phosphorylation by JAK tyrosine kinases，STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs （Stat1，Stat2，Stat3，Stat4，Stat5a，Stat5b，and Stat6）. Stat1，Stat3，Stat5a and Stat5b have wide activation profiles. Stat1 is activated by many different ligands including IFN family （IFN-a，IFN-b，IFN-r，and IL-10），gp130 family （IL-6，IL-11，LIF，CNTF，and G-CSF-1），and receptor tyrosine kinases （EGF，PDGF，and CSF-1）. Stat1 has two forms，the 91 kDa STAT1 and the 84 kDa STAT1B，which are coded by the same gene with splicing variant.
應用類型
Western blotting （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. The antibody recognizes both alpha （91 kDa） and beta （84 kDa） subunits of STAT1 in samples from human， mouse， and rat origins.
免疫原
Synthetic peptide surrounding amino acid 672 of rat Stat1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的Stat1蛋白 發生免疫反應.
保存建議
提供的Stat1抗體 產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA和0.01%硫柳汞的PBS緩沖液中.請將該Stat1抗體 產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
