AMPK2 alpha2 is a catalytic subunit of the AMP-activated protein kinase （AMPK）. AMPK is a heterotrimer consisting of an alpha catalytic subunit，and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses，AMPK is activated，and thus phosphorylates and inactivates acetyl-CoA carboxylase （ACC） and beta-hydroxy beta-methylglutaryl-CoA reductase （HMGCR），key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
應用類型
The antibody can be used for ELISA （0.25 ug/ml） and Western blotting （0.5 – 2.5 ug/ml）.
免疫原
Synthetic peptide selected from the C-terminal region of human AMPK
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠種屬來源的AMPK?2蛋白發生免疫反應.
保存建議
提供的AMPK?2抗體產品為100 ug 無色溶液，其濃度為0.25 mg/ml，溶解于包含有0.09% （W/V） 疊氮鈉的PBS緩沖液中.請將該AMPK?2抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
