PTP1B is the founding member of the protein tyrosine phosphatase （PTP） family，which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif，which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth，differentiation，mitotic cycle，and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase，as well as JAK2 and TYK2 kinases，which implicated the role of this PTP in cell growth control，and cell response to interferon stimulation.
應用類型
The antibody can be used for ELISA （0.25 ug/ml）， Western blotting （0.5 – 2.5 ug/ml）.
免疫原
Recombinant protein encoding amino acids 1-321 of human PTP1B
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠種屬來源的PTP1B蛋白發生免疫反應.
保存建議
提供的PTP1B抗體產品為100 ug 無色溶液，其濃度為0.25 mg/ml，溶解于包含有0.09% （W/V） 疊氮鈉的PBS with 0.09% （W/V） sodium azide..請將該PTP1B抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
