CD40，also known as bp50 or CDW40，is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand （CD40L），a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation，antibody class switching，modulation of apoptosis in the germinal center through interaction with T cells expressing CD40L，and activation of CD4+ T cells. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.
應用類型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 246 of human CD40 Ligand
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的CD40L蛋白發生免疫反應.
保存建議
提供的CD40L抗體產品為100 ug 無色溶液，其濃度為0.5 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該CD40L抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
