Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis （IAPs）. These proteins contain a BIR （baculovirus IAP repeat） domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and –7. For example，XIAP，cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9，thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors，they may inhibit apoptosis by additional mechanisms.
應用類型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Jurkat cell lysate and rat kidney tissue lysate can be used as positive controls.
免疫原
Synthetic peptide surrounding amino acid 530 of human cIAP-1
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的cIAP-1/HIAP-2蛋白發生免疫反應.
保存建議
提供的cIAP-1/HIAP-2抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該cIAP-1/HIAP-2抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
