Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis （IAPs）. These proteins contain a BIR （baculovirus IAP repeat） domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and –7. For example，XIAP，cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9，thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors，they may inhibit apoptosis by additional mechanisms.
應用類型
Western blot analysis （0.5-4 ug/ml）. However， the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.
免疫原
Synthetic peptide surrounding amino acid 510 of human cIAP-2
來源宿主
兔
反應性
經檢測驗證，可與人、小鼠、大鼠種屬來源的cIAP-2/HIAP-1蛋白發生免疫反應.
保存建議
提供的cIAP-2/HIAP-1抗體產品為100 ug 無色溶液，其濃度為0.2 mg/ml，溶解于包含有30%甘油， 0.5% BSA， 0.01%硫柳汞的PBS （pH 7.2）緩沖液中.請將該cIAP-2/HIAP-1抗體產品置于-20 ℃冷凍保存，建議分裝使用以避免反復凍融.
